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Microlab NIMBUS

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The Microlab NIMBUS is a compact, multi-channel automated liquid handler, offering speed, flexibility, ease-of-use and superior pipetting performance…at a surprisingly affordable price. NIMBUS comes available in three highly configurable base platforms:

  • NIMBUS96: 96-channel multi-pipetting head (MPH)
  • NIMBUS4: 1 – 4 independent liquid channels
  • NIMBUS ENCLOSED: Available with 96-channel multi-pipetting head,1 – 2 independent 5mL liquid channels or 1 – 4 independent 1mL liquid channels

 

 

 

 


NIMBUS is a small-scale liquid handler designed for space and budget-conscious labs that require:

  • high pipetting accuracy and precision
  • low/medium throughput
  • small footprint
  • affordability

A cumulative blend of enabling technology, a range of integrated options, intuitive software and the backing of HAMILTON’s renowned service and applications support makes the NIMBUS an indispensable tool for budget and space-constrained labs. Using proven air displacement pipetting, NIMBUS offers the same liquid handling performance as higher end systems, yet at a fraction of the price. Choice of either a high-speed 96 channel MPH or up to four independent liquid channels, and a range of options including the enclosure and flexible labware gripper makes NIMBUS a valuable addition to any biopharma or research lab.

The NIMBUS is useful in:

Ham_nimbus_apps

Characterization:

Compressed O-Ring Expansion (CO-RE)

Many of today’s applications require precision in tip attachment and positioning. To accomplish this, Hamilton utilizes proprietary Compressed O-Ring Expansion (CORE) technology. CO-RE technology attaches disposable tips using a highly robust lock-and-key style mechanism. This enables a positional precision of + 0.1mm on all axes. The system requires virtually no vertical force for tip attachment or ejection, thus eliminating mechanical stress and minimizing the production of aerosols. Reduced stress also improves overall system reliability and throughput.


Air Displacement Pipetting
air-tech

NIMBUS utilizes proven air displacement pipetting, similar to high precision handheld electronic pipettors. Benefits of this technology include: Reduced risk of contamination or sample dilution (no system fluid) High pipetting accuracy and precision from sub-microlitre to large (>1 mL) volumes Increased robustness and easier maintenance owing to lack of system liquids, diluters, valves or complicated tubing


Anti-Droplet Control (ADC)

This technology serves to compensate in real time for pressure changes in the liquid channels caused by high vapor pressure of volatile solvents. Upon activation, ADC prevents inadvertent dripping from the channels, reducing the risk of contaminating the deck. ADC detects and reacts on pressure changes in the channels that are caused by the high vapor pressure of volatile solvents in real time. This feature is available with single pipetting channels


Monitored Air Displacement (MAD)

By monitoring the air-based pipetting action, NIMBUS can detect clots or empty wells during the aspiration step in real time. It can also be used to pipette highly volatile solvents. With MAD your pipetting robot gives you a feedback on the real-time tracking of the aspiration performance. Therefore MAD delivers a confirmation of the successful aspiration. Monitored Air Displacement eliminates uncertainty in automated assays by providing reliable, consistent walk-away automation.


Total Aspiration and Dispense Monitoring (TADM)

During crucial sample transfers (e.g. in vitro Diagnostics or DNA Forensics), parameters may be set to monitor, in real time, both the aspiration and dispense steps. TADM verifies with a traceable digital audit trail that a sample has been successfully transferred.


Liquid Level Detection (LLD)

NIMBUS uses LLD technology to determine liquid levels in tubes and plates located on the pipetting deck. There are two modes of LLD: capacitative LLD (c-LLD), used to detect most types of liquids in most types of vessels; and pressure-based LLD (p-LLD), which can detect virtually all fluid types, including foaming liquids and non-conductive organic solvents. cLLD is available (MPH channels A1, B2, G11 & H12); pLLD is available. For even greater confidence in COMPRESSED O-RING EXPANSION (CO-RE) LLD, a dual mode LLD approach may be used.


Technical Data:

NIMBUS4 Functional & Performance Specifications

Parameters Specifications
Open Physical Dimensions (1000 μL)
Length:
Width:
Height:
37.4 in (95 cm)
20.1 in (51.1 cm)
30.3 in max (76.9 cm)
Standard Enclosed Physical Dimensions
Length:
Width:
Height:
41.2 in (104.6 cm)
27.9 in (70.9 cm)
32.7 in max (83.1 cm)
Extended Enclosed Physical Dimensions
Length:
Width:
Height:
53.5 in (135.9 cm)
27.9 in (70.9 cm)
35.0 in max (88.9 cm)
Large Extended Enclosed Physical Dimensions
Length:
Width:
Height:
65.5 in (166.4 cm)
27.9 in (70.9 cm)
35.0 in max (88.9 cm)
Pipetting specifications for disposable tips
Disposable tip size:10 μL:
10 μL:
10 μL:
50 μL:
50 μL:
50 μL:
300 μL:
300 μL:
300 μL:
1000 μL:
1000 μL:
1000 μL:
Volume

1 μL
5 μL
10 μL
1 μL
5 μL
50 μL
10 μL
50 μL
300 μL
10 μL
100 μL
1000 μL

Trueness
|R| (%)
5.0%
2.5%;
1.5%
5.0%
2.5%
1.5%
3.0%
1.5%
1.0%
7.5%
2.0%
1.0%
Precision
CV (%)
5.0%
2.0%
1.5%
5.0%
2.0%
1.0%
2.0%
1.0%
1.0%
3.5%
1.0%
1.0%
For pipetting of less than 10 μL HAMILTON recommends 10 μL/50 μL volume disposable tips to achieve highest pipetting precision.
Liquid level detection
Independent Channels:
Capacitive liquid level detection (cLLD)
Pressure liquid level detection (pLLD)
Deck Capacity 8-12 positions
Communication type Ethernet

Labware Gripper Specifications:

Absolute positioning accuracy X, Y, Z = 0.5 mm
reproducibility X, Y, Z = 0.25

NIMBUS384 Functional & Performance Specifications

Parameters Specifications
Open Physical Dimensions (1000 μL)
Length:
Width:
Height:
37.4 in (95 cm)
20.0 in (50.8 cm)
30.0 in max (76.2 cm)
Extended Enclosed Physical Dimensions
Length:
Width:
Height:
52.75 in (134 cm)
29.5 in (74.9 cm)
34.5 in max (87.6 cm)
Large Extended Enclosed Physical Dimensions
Length:
Width:
Height:
65.5 in (166.4 cm)
29.5 in (74.9 cm)
35.5 in max (87.6)
Pipetting specifications for disposable tips – 384-channel CO-RE head
Disposable tip size:50 μL:
50 μL:
50 μL:
Volume

0.5 μL
1.0 μL
50.0 μL

Trueness
|R| (%)
1.0%
1.0%
1.0%
Precision
CV (%)
6.0%
4.0%
2.0%
The 384-channel CO-RE head uses
special 50 μL – 384 tips (usable as 96
channel CO-RE head with the 4 to 1 tip
adapters). Stacked tip-racks available to
increase deck capacity (NTR).
Liquid level detection
384-channel CO-RE head:
cLLD – (Channels A5 and P24)
Deck Capacity 11 – 12 positions
Communication type Ethernet

Labware Gripper Specifications:

Absolute positioning accuracy X, Y, Z = 0.5 mm
reproducibility X, Y, Z = 0.25 mm

NIMBUS96 Functional & Performance Specifications

Parameters Specifications
Open Physical Dimensions (1000 μL)
Length:
Width:
Height:
37.4 in (95 cm)
20.1 in (51.1 cm)
30.6 in max (77.7 cm)
Extended Enclosed Physical Dimensions
Length:
Width:
Height:
52.75 in (134 cm)
29.5 in (74.9 cm)
34.5 in max (87.6 cm)
Large Extended Enclosed Physical Dimensions
Length:
Width:
Height:
65.5 in (166.1 cm)
29.5 in (74.9 cm)
34.5 in max (87.6 cm)
Pipetting specifications for disposable tips – 96-channel CO-RE head
Disposable tip size:10 μL:
10 μL:
10 μL:
50 μL:
50 μL:
50 μL:
300 μL:
300 μL:
300 μL:
1000 μL:
Volume

1 μL
5 μL
10 μL
1 μL
5 μL
50 μL
10 μL
100 μL
300 μL
1000 μL

Trueness
|R| (%)
5.0%
2.5%;
1.5%
5.0%
2.5%
1.5%
3.0%
1.5%
1.0%
1.0%
Precision
CV (%)
5.0%
2.0%
2.0%
5.0%
2.0%
0.75%
2.0%
2.0%
2.0%
0.75%
Liquid level detection
96-channel CO-RE head:
Capacitive liquid level detection (cLLD)
(Channels A1, B2, G11 and H12)
Deck Capacity 11 or 12 positions
Communication type Ethernet

Labware Gripper Specifications:

Absolute positioning accuracy X, Y, Z = 0.5 mm
reproducibility X, Y, Z = 0.25 mm

 


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