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Microza Hollow Fiber Modules

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Polymeric Membrane Morphology

Microza* ultrafiltration membranes are unique in their construction. Every membrane has an asymmetric structure,with a membrane layer both on the inside, and on the outside of the fiber, overlaying a core comprising a very open support for excellent flow characteristics, and a central strengthening layer for outstanding fiber durability in long-term service. Microza ultrafiltration membranes are resistant to flow in both directions, so there is no risk of delamination or membrane rupture during accidental back-pressure. In fact, in many installations, backpulsing can be used to maintain flux during extended run times.

Microza micofiltration membranes have smooth inner and outer membrane skins with a highly porous symmetrical support structure giving high-flow rates. These modules can also be backflushed.

All Microza membranes have surfaces that minimize entrapment and facilitate cleaning. All Microza membranes are manufactured in a single step, and are not composed of laminates. Membranes and modules are subjected to rigorous quality control to ensure consistency of performance, durability in service, and module integrity for the most demanding applications.


Microza Module Types

Microza hollow fiber modules are available with housings made from polysulfone (native, clear), filled polysulfone (white, opaque), and polyvinylchloride (PVC). Polysulfone modules will withstand autoclaving and in some cases steaming. Clear polysulfone modules are recommended for more critical pharmaceutical applications. Filled polysulfone and PVC modules are ideally suited to long term installations where light might cause biofilm to form, or for bulk processes involving light sensitive materials. PVC modules are idea for use in feed water systems and bulk processes.

Microza modules are available with industry standard clamp fittings on the feed and retentate side, and some with quick connects. All steamable modules designed for long term use in critical applications such as perfusion have sanitary clamp connections on the feed/retentate and filtrate sides, or filtrate hose barbs on laboratory scale modules.

Characterization:

Polyacrylonitrile (PAN)

PAN membranes are ideally suited to bulk process applications, such as the purification of enzymes. They exhibit high-strength, coupled with high flux rates, minimizing installation size. PAN has a low fouling characteristic for these applications, simplifying cleaning.

The AP and AV series of Microza hollow fiber ultrafiltration modules feature unique double-skinned proprietary polyacrylonitrile (PAN) membranes with dense internal layer. Available in 6,000, 13,000, 50,000 and 80,000 molecular weight cut-offs, the modules are used in a range of pharmaceutical applications especially in purification and processing of aqueous enzymes and protein solutions. 80,000 MWCO modules are especially useful for raw water pretreatment to pharmaceutical water purification plant.

Key Features
  • Hydrophilic polyacrylonitrile membrane provides low fouling and excellent flux recovery
  •  Combination of high-strength and high-capacity due to unique membrane construction
  • High-strength fiber allows reverse filtration to assist cleaning in difficult applications
  • Available in a range of sizes from 0.012 m2 (0.13 ft2) to more than 40 m(425 ft2)
  • Compatible for continuous operation up to 50 °C (122 °F)
  • Easily cleanable in most biological applications using minimum chemicals or detergents
  • Meets the specifications for biological tests listed in the current revision of USP for class VI plastics at 121 °C (249 °F)
  • LGV and LOV modules especially optimized for raw water duty
  • pH 2 -10

 

 

Polyolefin (P)

Polyolefin membranes are a good choice for bulk clarification processes where sterility is not essential. Nevertheless, P-membranes have good retention characteristics coupled with high flux rates. Availability in fine microfiltration retention ratings ensures protection of downstream processing equipment. .

The P series of Microza hollow fiber microfiltration modules feature unique proprietary membranes in polyolefin for general microfiltration applications. Available in 0.1 µm rating, the modules are used in a range of pharmaceutical applications especially in clarification of microbial cultures for enzyme production, clarification of natural product extracts, and nutraceutical production.

Key Features
  • Available different internal fiber diameters provides suitability for processes with varying particulate or colloidal loading
  • Broad chemical resistance ensures compatibility in a wide range of processing and cleaning conditions
  • Highly characterized,optimized void structure ensures reproducible separation efficiency and high throughput
  • High-strength fiber allows reverse filtration to optimize yield and performance in difficult applications
  • Available in a range of sizes from 0.09 m2 (1 ft2) to over 8 m2 (85 ft2)
  • P series compatible for continuous operation up to 50 °C
  • Meets the specification for biological tests listed in the current revision of USP for Class VI plastics at 121 °C

 

 

Polsulfone (PS)

Polysulfone membranes exhibit excellent resistance to pressure, temperature and aggressive cleaning regimes. Very low affinity and adsorption characteristics results in high product recoveries, and long service life.

Microza SP, SV and VP series hollow fiber ultrafiltration modules have a unique double-skinned proprietary polysulfone (PS) membrane with dense internal layer. Currently available in 3000, 4000, 6000, and 10000 molecular weight cut-offs, the modules are used in a range of pharmaceutical applications including pyrogen removal from water, buffer solutions active ingredients such as antibiotics, and concentration of protein solutions. SV modules are used for clarifying antibiotic and other broths used for small molecule active pharmaceuticals ingredients production.

Key Features
  • Combination of high-strength and high-flow due to unique membrane construction
  • Double-skin provides assurance of removal rating
  • High-strength fiber allows reverse filtration to assist cleaning in difficult applications
  • Available in a range of sizes from 0.015 m2 (0.16 ft2) to more than 12 m2 (125 ft2)
  • All SP and VP modules may be hot water sanitized: up to 95 °C – SIP and SLP, or 90 °C – SEP and SAP; and all may run continuously at 80 °C
  • SP Modules may be autoclaved in single use applications
  • VIP 6000 MWCO version steam-sterilizable up to 50 cycles at 125 °C at a differential pressure of 100 mbar
  • SV modules are designed for maximized recovery in bulk fermentation, limited to 50 °C
  • Compatible with a wide range of cleaning agents, up to 5000 ppm sodium hypochlorite or 4% sodium hydroxide
  • Meets the specification for biological tests listed in the current revision of USP for class VI plastics at 121 °C
  • pH range 1 – 14

 

Polyvinylidenefluoride (PVDF)

PVDF membranes are widely used for the filtration of biological solutions. In hollow fiber format, these membranes show excellent retention characteristics, allowing use in critical applications where absolute removal over long periods is required. Lower non-specific binding than many PS membranes used in protein recovery applications ensures excellent results in leading-edge biotechnology processes. PVDF membranes are steamable in situ for additional process security. PVDF exhibits superior chemical resistance to many other polymers used in microfiltration processes.

The U series of Microza hollow fiber microfiltration modules feature unique proprietary membranes in specially resistant PVDF for microfiltration applications. Available in 0.2 µm (UM series) and 0.65 µm (UJ series) rating, the modules are used in a range of pharmaceutical applications especially in cell harvesting, perfusion cell culture, viral vector production, and clarification of microbial extracts.

Key Features
  • Low non-specific protein binding for long term flux maintenance in cell culture applications
  • Available different fiber diameters allows optimization to different particulate or colloidal loadings
  • Superior chemical resistance of Microza PVDF ensures compatibility in a broad range of processing and cleaning applications
  • Highly characterized,optimized void structure ensures reproducible separation efficiency and high throughput
  • High-strength fiber allows reverse filtration to optimize yield and performance in difficult applications
  • Available in a range of sizes from 0.02 m2 (0.21 ft2) to 5 m2 (54 ft2)
  • U series can operate continuously in processes up to 80 °C and may be steamed in situ at 125 °C for 20 cycles
  • Meets the specification for biological tests listed in the current revision of USP for Class VI plastics at 121 °C
  • pH 2 – 10

 

 

 


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