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ImageXpress Micro XLS (IXM)

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Widefield High-Content Analysis System

The ImageXpress® Micro XLS System is a wide field automated microscope capable of fluorescent, transmitted light, and phase-contrast imaging of fixed- or live-cell assays, tissues and small organisms. Speed, flexibility and quality are assured with 3x field-of-view, industry-leading stage and auto focus control, the broadest range of research-grade objective lenses (1x-100x) available, multiple filter options, and a suite of MetaXpress® Software solutions to facilitate and optimize image analysis.

Fast, flexible and robust wide field high-content imaging for fixed- or live-cell assays.

• One system, unlimited configurations
• Accelerate screens to > 50,000 wells per day
• Expand assay window with 3-log  dynamic range
• One 384-well, one image
• Reliable assays with < 5% CV of  intensities across a plate
• Complete solution for HCS with integrated  software and database packages




Boost your high content imaging with ImageXpress Micro XLS System


IXM System Workflow Demonstration

3D Imaging of Cancer Spheroids


Blood cells circulating through zebrafish


 Zebrafish heartbeat






  • Fewer images per well and shorter imaging time with a field of view that is 3x larger than industry standard
  • A breadth of applications enabled by objectives ranging from 1x to 100x, 0.05 to 0.95 NA for air and 1.4 NA for oil, capturing a variety of cellular and intra-cellular events
  • Accurate stage positioning for capturing high-resolution tiled or stitched images with fully-automated 100 nm resolution voice coil-driven stages, thereby minimizing X-Y stage jitter and ensuring repeatability of extended live-cell experiments
  • Up to 5x faster read times while minimizing photobleaching with industry-leading autofocus using a dedicated 690 nm focus laser and ultra-fast sensors
  • High-throughput screening captures > 10 million cells/hour in a low-resolution, whole-well, 3 color cell scoring application, or > 1 million cells/hour in a high resolution two-color assay
  • Minimized user intervention using automated 5-position filter cube changer, facilitating multiplex assays with up to five filter sets and four objectives for a single experiment
A 5-color assay achieved with multiple filters. Mouse embryo sections
Blue = DAPI, Green = FITC, Red = TRITC, Orange = Cy5
  • Modular design allowing for transmitted light, phase contrast, environmental control, fluidics, light source and external filter wheel selection
  • Extensive sample compatibility from slides to plates (6- to 1536-well), thin to thick plate bottoms, glass to plastic, transwell, low profile- and low volume-plates
  • Integrated automation, 24/7 with 3rd party robotic plate handling system, enabling users to schedule multiple runs.

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